Improving CBF MRI using a Background Suppression in cASL with a Separate Labeling Coil
نویسندگان
چکیده
INTRODUCTION In arterial spin labeling (ASL) MRI of cerebral blood flow (CBF), pair-wise subtraction of adjacent non-labeled and labeled images often could not achieve complete cancellation of the background static tissue signal because of temporally fluctuating physiological noise. While background suppression (BS) by inversion nulling has been shown to improve CBF temporal stability (1–5), imperfect post-labeling inversion pulses compromise perfusion contrast. We previously proposed a background suppression in conjunction with continuous ASL approach (IR-cASL) (6), in which an inversion pulse was applied before the continuous labeling of arterial spin. In this work, we further developed this approach to include CBF quantitative for multi-slice acquisitions in which the amount of background suppression varies due to T1 recovery with multislice acquisition. Comparisons with cASL were made in the same animals. In addition, we tested the efficacy of improving CBF accuracy in stroke rats.
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Background suppression in arterial spin labeling MRI with a separate neck labeling coil.
In arterial spin labeling (ASL) MRI to measure cerebral blood flow (CBF), pair-wise subtraction of temporally adjacent non-labeled and labeled images often can not completely cancel the background static tissue signal because of temporally fluctuating physiological noise. While background suppression (BS) by inversion nulling improves CBF temporal stability, imperfect pulses compromise CBF cont...
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